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Mitochondrial Biology in neuronal function and disease

University of Bonn
Empirical & clinical neuroscience
About this course

The following content will be covered by the practical course:

  • Isolation of mitochondria
  • Blue native electrophoresis to study mitochondrial protein complexes.
  • Activity assays of respiratory chain complexes
  • Membrane potential measurements
  • Studies of mitochondrial morpholog
  • Protein-protein interaction studies
Learning outcomes

The students will get an overview about state-of-the-art techniques to study mitochondrial functions and mitochondrial dynamics. A set of cells with different mutations affecting mitochondrial functions will be analyzed using a broad range of
biochemical and cell biological assays. By combining these assays, the students will obtain an overview on how different mitochondrial functions such as respiratory activity, dynamics, protein import and protein quality control are interconnected and result in mitochondrial deficiency.

Prerequisites for participation

None

Necessary language skill
English
Semester(s) in which the module takes place
Summer Semester
Course type
Lecture + Practical + Seminar
Course level
Masters
Course start date
01 Jul 2024
Course end date
26 Jul 2024
Involvement period
4 weeks
Teaching mode
Local
Local attendance
Required
Workload in ECTS
7.5
Graded
Yes
Person in charge of module
Prof. Dr. Thomas Becker
Local module ID
WPM 33