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Information processing by neuron-glia assemblies

University of Bonn
Empirical & clinical neuroscience
About this course

Topics covered include:

  • mechanisms of neuron-astrocyte signal exchange in the hippocampus and their relevance for synaptic transmission and its plasticity, for hippocampus-dependent cognitive processes and behaviors such as spatial navigation
  • research methods will be selected from:
    • multiphoton fluorescence imaging and its applications for studying astrocyte/neuron signaling (e.g. Ca2+ imaging) and structural plasticity
    • advanced imaging techniques of optical indicators (e.g. FRET, FLIM) and indicator development (e.g. in HEK cells, acute brain slices)
    • electrophysiological methods like the patch clamp technique
    • super-resolution microscopy (expansion microscopy)
    • introduction to behavioral analyses (e.g. spatial memory, machine-learning based analysis)
Learning outcomes

Students will receive an introduction to the concepts of information processing by mixed cellular networks (i.e. neurons and astrocytes) and hands-on experience in their experimental investigation. The focus is on the hippocampus and its cognitive role. Methods include multiphoton fluorescence imaging and electrophysiology, their combinations, super-resolution microscopy and behavioral analyses.

Prerequisites for participation

45 ECTS

Necessary language skill
English
Interval at which Module/Course is offered
Summer and Winter Semesters
Semester(s) in which the module takes place
Winter Semester
Course type
Practical + Seminar
Course level
Masters
Course start date
28 Oct 2024
Course end date
20 Dec 2024
Involvement period
8 weeks
Teaching mode
Local
Local attendance
Required
Workload in ECTS
15
Graded
Yes
Person in charge of module
Prof. Dr. Christian Henneberger
Local module ID
WPP 30