The course covers the measurement of some common parameters for diagnostics and monitoring of patients. Origin of the signals, electrodes for registration, technical construction of sensors and amplifiers as well as registration methods. Measurements of electrocardiograph ECG, electroencephalograph EEG, electromyography EMG and others. Also measurements of blood pressure, blood flow in vessels, use of ultrasound for measurements and measurements of ventilation. Vital signs are considered and assessed. Requirements for CE marking and FDA approval are treated. Use of Laplace transform for describing sensors, amplifiers and their transfer functions. Error estimation and treatment is covered. In the course an amplifier for measurement and registration of different signals is a central theme. Students build an amplifier and calculate his main properties. They learn to connect sensors to the amplifier and realise how the complete system works. Practical exercises are done for practising. Main theme of the course is how knowledge in physiology, physics, mathematics and electronics is used to define a measurement system and design it. Prerequisites for the course are these fundamental courses of biomedical engineering.