The purpose of this course is to enable doctoral students and other participants to gain an understanding of the major neuroinflammatory diseases and the key players involved, including the interaction between the central nervous and immune systems. An additional purpose is that those who participate in the course learn to understand critical aspects of creating and using experimental systems to model neuroinflammatory diseases.
The course is offered full time, Monday-Friday, 9:00-17:00 at the Center for Molecular Medicine (CMM) on Karolinska University Hospital, campus Solna, building L8, lecture hall and seminar rooms.
This course is given jointly by the doctoral programmes Allergy, immunology and inflammation (Aii) and Neuroscience (Neuro
The course gives an overview of clinical symptoms, signs, pathology, treatments and diagnostic criteria for the most important neuroimmunological diseases including Multipel Sclerosis, Myastenia Gravis, Guillain-Barré syndrome/Chronic inflammatory demyelinating polyradiculoneuropathy, and Narcolepsy. An overview of experimental models of neuroimmunological diseases, with an emphasis on techniques for genetic analysis (designing and creating genetically mofified rats and mice, etc). Key molecular concepts in neuroinflammation are covered such as immune mechanisms (the blood-brain barrier (BBB), major cell players, MHC-TCR interaction) as well as key tissue degeneration/regeneration. Different techniques used to study neuroinflammation are discussed including imaging, high-throughput genotyping, expression analysis and proteomics.
No prerequisite courses, or equivalent, demanded for this course.
SELECTION
Selection will be based on:
1) the relevance of the course syllabus for the applicant’s individual study plan/research (according to written motivation).
2) start date of doctoral studies (priority given to earlier start date).