Brain function depends on a constant supply of glucose and oxygen from blood vessels. Efficient communication between neural cells and vessels is essential for correct brain function and relies on the selective transport of nutrients across the blood-brain barrier. Brains are particularly vulnerable to dysfunction of blood flow and loss of barrier properties, which can lead to dementia and neurodegenerative disease. The purpose of the course is to deepen the understanding of concepts underlying cerebrovascular development, cell signalling, imaging methods and vascular contributions to neurodegenerative diseases.
At the end of the course, the doctoral student should be able to:
· Describe different cognitive domains and their general relationship to neural correlates.
· Define and describe common neuropsychological concepts and techniquesfor measurement.
· Use critical thinking when motivating or criticizing neuropsychological investigationmethodologies and cognitive diagnostics in aging.
· Explain the basic principles of cognitive aging and contrast “normal” with early-stage pathological aging in a critical way.
· Discuss how prevention and lifestyle changes have the potential to protect against negativeimpacts on the brain and cognition.
Understanding of basic cell biology and molecular biology.