CAPTAIN Trials (I and II) – a new horizon in TBI Treatment
Traumatic Brain Injury (TBI) remains one of the major global health challenges, representing a leading cause of disability and death. In 2016 alone, approximately 27 million new cases of TBI contributed to the global burden of disease. This lecture focuses on the CAPTAIN-RO trial, through the introduction of multidimensional analysis — a novel methodological approach in neurorehabilitation research.
The goal of this lecture is to provide a theoretical and methodological understanding of multidimensional analysis in clinical neurorehabilitation, using the CAPTAIN-RO trial as a case study. Students will learn how this approach enhances precision, interpretability, and translational value in TBI research.
At the end of this lecture, students will be able to:
- Explain the rationale for applying multidimensional analysis in TBI clinical trials.
- D9cribe the CAPTAIN-RO trial design, objectives, and methodological innovations.
- Differentiate between traditional single-criterion approaches and multidimensional outcome frameworks.
- Evaluate how full-scale outcome measurement enhances statistical power and clinical insight in neurorehabilitation research.
- Overview of TBI as a global health challenge.
- Introduction to the CAPTAIN-RO trial design and aims.
- The concept and advantages of multidimensional analysis.
- Methodological implications for neuroprotective treatment research.
- Future perspectives for applying multidimensional approaches in TBI and related fields.
